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Utilizing the GCRLE grant, Munakata and Namekawa will appear more intently at how oocytes are genomically primed and stored for later use. They'll investigate the role of a chromatin remodeler in oocyte survival and fertility.
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Munakata and Namekawa will Review mice with usual and mutated variations from the chromatin remodeler. As being the mice mature and experienced, they will observe if the presence or absence of this protein triggers discrepancies within the arrangement of DNA spools inside the animals’ oocytes. And they'll watch whether this, consequently, alters the pattern of gene expression after a while.
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“The organization of chromatin influences which genes is often expressed,” states Namekawa. That’s mainly because the specific destinations in the spools, and the spacing amongst them, determines which stretches of DNA could be accessed by molecules termed transcription variables, which latch on to genes and switch them on.
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Yasuhisa Munakata, a postdoctoral fellow in the College of Biological Sciences, has acquired a grant to check how egg cells within the ovary modify eventually.
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